Neuromodulation and Neuroplasticity in Sleep-Disrupted Post-Traumatic Epileptogenesis

This project explores the intricate relationship between sleep disruption and post-traumatic epileptogenesis in the context of military health. For the first time in the context of post-traumatic epilepsy (PTE), we are investigating the impact of non-invasive neuromodulation using repetitive transcranial magnetic stimulation (TMS) on post-traumatic neuroplasticity and mechanisms of inhibitory control. This research seeks to understand how chronic sleep disruption prior to traumatic brain injury (TBI) influences recovery and contributes to the development of PTE, a serious condition marked by recurrent seizures that can manifest well after the initial injury. Our study focuses on identifying biomarkers for PTE risk and developing novel therapeutic targets that could mitigate this risk in both military and civilian populations.

Funding: This research is supported by the US Army CDMRP Virtual Post-Traumatic Epilepsy Research Center Faculty Award, with a grant amount of $758,808. The funding aids in pursuing innovative approaches to understand and prevent PTE, enhancing our understanding of the neuromechanisms involved in TBI and sleep-related disorders.